Vitamin Tolerance of Animals (1987) / Chapter Skim
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9 Vitamin B6 (Pyridoxine)
9 Vitamin B6 (Pyridoxine)
Pages 58-63
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From page 58... ...
The synthetic form of pyridoxine used for dietary supplementation is generally pyridoxine hydrochloride (PN HCl) although some researchers have used the free base.
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From page 59... ...
Workers have fed diets containing up to 1,430 mg of PN HCl per kg to growing and breeding rats over prolonged periods with no adverse effects (Brie and Thiele, 1967; Cohen et al., 1973; Stowe et al., 1974; AltonMackey and Walker, 1978; Kirksey and Susten, 1978; Sloger and Reynolds, 1980; Mercer et al., 1984~. In addition, daily oral doses of up to 2.5 mg of PN · HCl/rat over a prolonged period, or oral doses of 9 mg of PN HCl given on each of 2 successive days did not result in any adverse effects (Unna and Antopol, 19401.
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From page 60... ...
60 ~4 Pi 4= To ~ C: ¢ .o E ~ W C o E by .= be ¢; so cn 1:: ·= ~ .~ ¢~o ¢ ~ o ~ cn Z
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From page 61... ...
61 ~a to to (s)
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From page 62... ...
The available data suggest that rats may safely be fed diets containing up to 500 mg of PN/kg for less than 60 days, or up to 250 mg of PN/kg for more than 60 days. Estimates of the dietary levels of PN HCl that produce specific tissue and body fluid saturation in rats following exposure for more than 60 days are: muscle, 2.4 mg/kg; liver, 4.8 mg/kg; milk, 9.6 mg/kg.
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From page 63... ...
Hess.1980. Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy)
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