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Vitamin Tolerance of Animals (1987) / Chapter Skim
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10 Folic Acid
Pages 64-66

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From page 64...
... Folate requirements have been determined to range late coenzymes are used to synthes~ze meth~on~ne ano purine rings and convert deoxyuridinemonophosphate to deoxythymadinemonophosphate. The folate coenzymes, S-adenosyl methionine and vitamin B~2, are therefore responsible for the movement of one-carbon units in metabolic pathways.
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From page 65...
... These forms may have up to eight additional glutamic acid residues attached to the terminal glutamate of folic acid in an amide linkage as a poly-^y-amide. The polyglutamates are the reduced active coenzyme forms in animal tissues.
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From page 66...
... Acute renal failure in the folatetreated rat: Early metabolic changes in various structures of the nephron. Kidney Int.
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Key Terms

  • massive doses
  • rat kidney
  • lactic acid
  • acute renal
  • acid bacteria

  • glutamic acid
  • pteridine ring
  • metabolic changes
  • folate requirements
  • renal failure

  • reduced polyglutamates
  • enterohepatic circulation
  • animal studies
  • renal growth
  • subsequent metabolism

  • thymine biosynthesis
  • pharmacological responses
  • studies demonstrated
  • studies using
  • dissimilar effect

  • renal hypertrophy
  • substantial enterohepatic
  • purine rings
  • generic descriptor
  • effects following

  • enzymatically reduced
  • folate requirement
  • growth factors
  • vitamin bit
  • pteroic acid


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