Microbial and Phenotypic Definition of Rats and Mice Proceedings of the 1998 US/Japan Conference (1999) / Chapter Skim
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Pages 56-60
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From page 56... ...
However, as shown in this study, caesarian section produced a bottleneck effect on Jcl:Wistar, and Iar:Wistar is genetically different from Crj:Wistar. Thus, subcolonies exist.
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From page 57... ...
1. History, Genetics, and Wild Mice.
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From page 58... ...
Frequently there are unexpected interactions with downstream pathways whereby the genetic background can markedly influence the phenotype resulting from a specific genetic change. There also have been gene knockout mice declared as having no abnormal phenotype; but when subsequent more specialized analyses were completed, striking abnormal phenotypes were discovered.
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From page 59... ...
PHILIP A WOOD 59 can and should be available for investigators at most biomedical research institutions, but the secondary level of assessment will likely require more specialized expertise and equipment and could be integrated into nationally based networks established for phenotype assessment.
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From page 60... ...
This is an important, developing area of biomedical research that will take advantage of the numerous genetic modeling approaches provided by rodents. There already are many behavioral differences observed among the inbred strains of rodents.
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