Review of the Hanford Thyroid Disease Study Draft Final Report (2000) / Chapter Skim
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2 Overview of the HTDS Draft Final Report and Organization of the Committee's Report
2 Overview of the HTDS Draft Final Report and Organization of the Committee's Report
Pages 42-48
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From page 42... ...
On the basis of data from the atomic-bomb survivors and other studies of radiation exposure, as described in the background section of the HTDS Draft Final Report, young children are considered to be more sensitive to thyroid disease as a consequence of exposure to ~ The NRC committee uses the term "prevalence" loosely as a convenient way to refer to "cumulative incidence", which is what was actually assessed by the HTDS.
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From page 43... ...
Outcome criteria, which define diagnostic criteria for various thyroid and parathyroid diseases and other changes, are also provided. Section V summarizes the field procedures and methods and the results of data collection, including detailed information on how the cohort was defined and its members were identified, how study subjects were traced and recruited, how telephone interviews were conducted, and how doses were estimated.
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From page 44... ...
Section VT discusses three special considerations related to the conduct of the HTDS. The first was an assessment of the feasibility of conducting a similar health study in the nine American Indian tribes and nations near the Hanford site; it discusses the steps taken to determine the feasibility and the decision that such a study would have insufficient statistical power to detect an increase in thyroid disease caused by Hanford releases.
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From page 45... ...
Radiation doses to the thyroid from Hanford AT are summarized on the basis of calculations derived with the CIDER computer program developed as part of the HEDR project; these calculations were based on a person living "in area" or "out of area" from December 1944 to the end of 1957. For each study participant, 100 dose estimates were calculated, and the median of the 100 estimates was used as the best estimate of the person's dose.
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From page 46... ...
To provide a thorough and balanced review of the Draft Final Report and its communication to the public, the subcommittee undertook a number of activities. We met on February 4-5, 1999, in Atlanta, Georgia, on March 29-30, 1999, in Augusta, Georgia, and on August 30-31, 1999 in Washington, DC, to review the report; during the same period, we requested additional information from the HTDS and HEDR investigators.
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From page 47... ...
Because the HTDS was an epidemiologic study with substantial public-health implications and because there was intense public interest in the Draft Final Report, the subcommittee felt that the study and the draft report should be thoroughly reviewed both for its technical aspects and for its effectiveness and balance in communicating to the public. We therefore went beyond the six questions that were posed by CDC and considered additional issues pertaining to scientific quality.
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From page 48... ...
48 Review of the HTDS Draft Final Report Statistical power and interpretation. Communication of results.
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