Future Biotechnology Research on the International Space Station (2000) / Chapter Skim
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Appendix A: Hardware Available or in Development and Schedule for Biotechnology Research on the International Space Station
Appendix A: Hardware Available or in Development and Schedule for Biotechnology Research on the International Space Station
Pages 51-61
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Appendixes
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The functionality of the DCAM, PCAM, and VDA-2 hardware is identical to its functionality when flown in an enclosure. However, the number of DCAM trays, PCAM cylinders, or VDA-2 trays flown may vary owing to differences in the ambient stowage volume.
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The hardware consists of a liquid nitrogen dewar and aluminum insert tube, sealed Tygon capillary sample tubes, sample bundles, and an electronic temperature monitoring system. The dewar vessel consists of two flasks with the inner space evacuated to create a thermal vacuum insulation.
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This system employs a Michleson-Morley phase-shift interferometer to produce images showing density changes in solution as a protein crystal forms. The system comprises three major systems an interferometer, six fluid assemblies with test cells, and a flight data system.
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Devices in Early Definition Phase for in Situ Observation of Crystallization on Orbit Microscope Laser Light Scattering Apparatus. This device is being designed to permit scientists to determine the size and relative concentration of protein molecules attaching onto a crystal's surface.
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Plans for future improvements include using a 6K single chip CCD detector system currently under development by Bruker and redesigning the goniostat to allow the crystal to detector distance to expand to o 300 mm (which would enable the system to achieve a 500 A unit cell)
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Middeck Glovabox. This unit provides an enclosed space for experiment manipulation and observation for work in the several disciplines to be studied on ISS, including protein crystallization, fluid physics, combustion, and material science.
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This unit houses a single 125-ml rotating-wall perfused vessel in a controlled environment along with associated equipment for medium infusion/perfusion, temperature control, gas exchange, and independent rotation. Unlike ground-based rotating-wall bioreactors, in which laminar flow is set up to randomize the force vectors and to minimize the shear stress, the space-based vessels have rotating walls in order to produce Couette flow, which augments mass transport.
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Minus Eighty Degree Laboratory Freezer for ISS (MELFIJ. This unit will provide cooling down and storage for reagents, samples, and perishable materials in four dewars with independently selectable temperatures of -80°C, -26°C, and +4°C during on-orbit ISS operations.
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Current plans call for the BTF to provide each experimental module within it with power, gases (such as nitrogen and carbon dioxide) , thermal cooling, data acquisition, storage and processing, video and image analysis, data downlink, realtime control, resource allocation, research-grade water, and vacuum exhaust for one modular unit at a time.
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