Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000) / Chapter Skim
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10 A Research Agenda
10 A Research Agenda
Pages 401-408
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From page 401... ...
This chapter describes the approach used to develop the research agenda, briefly summarizes gaps in knowledge, and presents a prioritized research agenda. A section at the end of each nutrient chapter (Chapters ~ through 8)
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From page 402... ...
Also with vitamin C, there is little information relating levels of status indicators to functional sufficiency or insufficiency, because dose-dependent absorption and renal regulation of ascorbate allow body conservation during low intakes and limitation of plasma levels at high intakes.)
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From page 403... ...
Even if accurate assessments of body pools were possible and were obtained, such information would be useful in setting a requirement only if one could establish the body pool size at which functional deficiency occurs. The amount neecleci for restoration of biochemical status indicators to baseline values is not necessarily equivalent to the requirement for the nutrient.
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From page 404... ...
Research to ciate has inclicateci little cause for concern about the adequacy of vitamin E intake for apparently healthy people; deficiency states can be procluceci only as a result of genetic abnormalities in oc-tocopherol transfer protein, as a result of various fat malabsorption syndromes, or as a result of protein-energy malnutrition. However, the prevalence of these genetic abnormalities is unknown.
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From page 405... ...
Many of these studies have been conclucteci with supplemental intakes that are far above those that can be obtained from food, and some questions and controversy remain regarding the linkage of these antioxidant nutrients with increased risk of chronic clisease. For example, some clinical intervention trials have shown that in male long-term smokers, high closes of ,3-carotene supplements clici not decrease and may have increased their risk of lung cancer.
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From page 406... ...
Because ciata on the potential for ,3-carotene to produce increased lung cancer rates in smokers are conflicting, ongoing studies are neecleci to help resolve this issue. THE RESEARCH AGENDA Reporting Data Because the various forms of vitamin E are not interconvertible and because plasma concentrations of vitamin E clepenci on the affinity of hepatic oc-tocopherol transfer protein for the various forms, it is recommencleci that the relative biological potencies of the different forms of vitamin E be reevaluated.
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From page 407... ...
Thus, research is neecleci concerning the ULs for the carotenoicis. In aciclition, research would be helpful relative to the adverse effects of vitamin C, vitamin E, and selenium.
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