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Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000) / Chapter Skim
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Appendix G Options for Dealing with Uncertainties
Pages 458-462

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From page 458...
... The most significant inference uncertainties arise in risk assessments whenever attempts are macle to answer the following questions (NRC, 1994~: · What set or sets of hazard and close-response ciata (for a given substance) should be used to characterize risk in the population of interest?
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From page 459...
... These types of long-standing assumptions, which are necessary to complete a risk assessment, are recognized by risk assessors as attempts to clear with uncertainties in knowledge (NRC, 1994~.
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From page 460...
... The NRC committee recommencleci that regulatory agencies in the Uniteci States identify the neecleci inference options in risk assessment and specify, through written risk assessment guidelines, the specific options that will be used for all assessments. Agencies in the United States have iclentifieci the specific models to be used to fill gaps in ciata and knowledge; these have come to be called default options (EPA, 1986~.
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From page 461...
... A1though presenting a number of plausible risk estimates has the acivantage that it would seem to more faithfully reflect the true state of scientific unclerstancling, there are no well-establisheci criteria for using such complex results in risk management. The various approaches to clearing with uncertainties inherent in risk assessment are summarized in Table ~1.
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From page 462...
... 1986. Proposed guidelines for carcinogen risk assessment.
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Key Terms

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  • true state
  • risk characterization
  • allow risk
  • inference options

  • sensitive set
  • basic knowledge
  • carcinogen risk
  • uncertainties arise
  • uncertainties inherent

  • support alternatives
  • significant inference
  • definitive empirical
  • various approaches
  • provide explicit

  • inference uncertainties
  • default assumptions
  • scientifically plausible
  • assessments whenever
  • fill knowledge

  • faithfully reflect
  • information bearing
  • model uncertainties
  • human population
  • assessing nutrient

  • assessment issued
  • plausible options
  • whenever attempts
  • assessors complete
  • human response


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