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DPT Vaccine and Chronic Nervous System Dysfunction A New Analysis (1994) / Chapter Skim
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Evidence Bearing on Causality
Pages 6-10

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From page 6...
... The committee adopted a position of neutrality as they started considering and assessing the data, presuming neither the presence nor the absence of a causal relation. The committee used the five categories of conclusions used by the two previous committees, and followed the terminology of the Committee to Study the Adverse Consequences of Pertussis and Rubella Vaccines (IOM, 1991~.
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From page 8...
... Other controlled studies investigating the relation between DPT and acute encephalopathy (Gale et al., 1990; Griffin et al., 1990; Walker et al., 1988) did not detect a statistically significant elevated RR for acute necrologic illness after DPT, but those studies lacked sufficient statistical power to detect any but a very large risk.
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From page 9...
... a medical diagnosis of cerebral palsy or a related disorder. Detection by a physician of noticeable tremor, gross motor incoordination, fine motor incoordination, motor impersistence, muscle weakness or spasticity in one or more limbs, or abnormal tendon reflexes in one or more limbs indicated motor ~dy~function.
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From page 10...
... The authors then investigated the relation between DPT vaccination 7 days prior to the acute illness and long-term outcome in the original study children (Miller et al., 19931. Unfortunately, that analysis excluded the case children with the initial diagnosis of infantile spasms on the basis of a post hoc analysis showing no association between infantile spasms and earlier DPT immunization.
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Key Terms

  • control children
  • infantile spasms
  • acute event
  • days prior
  • adverse consequences

  • rubella vaccines
  • dpt immunization
  • cerebral disorder
  • earlier dpt
  • motor incoordination

  • rigorous manner
  • acute illness
  • serious acute
  • received dpt
  • studies lacked

  • fine motor
  • statistical power
  • sufficient statistical
  • original matched
  • children prior

  • nonfebrile severe
  • motor impersistence
  • started considering
  • initial diagnosis
  • neither physicians

  • including postinfectious
  • postinfectious encephalitis
  • national childhood
  • possibly biasing
  • concerns potential


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