Toxicological Risks of Selected Flame-Retardant Chemicals (2000) / Chapter Skim
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11 Antimony Pentoxide and Sodium Antimonate
11 Antimony Pentoxide and Sodium Antimonate
Pages 262-272
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From page 262... ...
The subcommittee used that information to characterize the health risk from exposure to pentavalent antimony. The subcommittee also identified data gaps and recommended research relevant for determining the health risk from exposure to pentavalent antimony.
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From page 263... ...
Lide 1991-1992 CAS Registry # 15432-85-6 Lide 1991 - 1992 Synonyms Sodium (meta) antimonate Lide 1991- 1992 Molecular weight 192.74 Lide 1991-1992 Physical state White, granular powder Lide 1991-1992 Solubility Slightly soluble in water; practically Lide 1991-1992 insoluble in HNO3; soluble in tartaric acid ant~monates function primarily as a stable colloid or synergist with halogenated flame retardants.
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From page 264... ...
This recommendation is based on studies of various organic and inorganic antimony compounds, some of which have a pentavaTent valence state. Oral exposure studies in Syrian hamsters with an antimony-tar/rate complex found only minute amounts of antimony were absorbed through the gastrointestinal tract (Felicetti et al.
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From page 265... ...
No other dermal toxicity data were identified for any pentavalent antimonates. iIn this section, the subcommittee reviewed toxicity data on antimony pentoxide and sodium antimonate, including the toxicity assessment prepared by the U.S.
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From page 266... ...
No F-344 rats died or developed abnormal gross pathology that were intratracheally instilled with a suspension of antimony pentoxide (3.5 ,ug /kg body weight) for 6 mo (American Biogenics Corp.
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From page 267... ...
Acute oral toxicity data for the pentavalent forms of antimony suggest that it is less toxic than the trivalent forms of antimony. Cancer There are insufficient cancer data on pentavalent antimonates from any route of exposure to calculate cancer potency factors.
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From page 268... ...
As a result, the noncancer risk associated with dermal exposure to antimony pentoxide or sodium antimonate, used as a flame retardant, cannot be characterized at this time. Inhalation Exposure Particles The assessment of the noncancer risk from inhalation of upholstery particles containing pentavalent antimony is based on the inhalation exposure scenario described in Chapter 3.
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From page 269... ...
Therefore, inhalation of antimony pentoxide vapor is not anticipated to pose a noncancer toxic risk when incorporated into furniture upholstery. Oral Exposure The assessment of noncancer risk from oral exposure to antimony pentoxide or sodium antimonate is based on the oral exposure scenario described in Chapter 3.
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From page 270... ...
There are no exposure measurements from any rouse of exposure. Based on the lack of toxicological data and possible concern from exposure to a structurally similar compound, antimony trioxide, the subcommittee recommends that the release rates into saline solution and air from fabrics treated with antimony pentoxide or sodium antimonate be investigated.
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From page 271... ...
1955. Toxicologic study of calcium halophosphate phosphors and antimony trioxide.
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From page 272... ...
1980. Renal clearance of pentavalent antimony (sodium stibogluconate)
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