Toxicological Risks of Selected Flame-Retardant Chemicals (2000) / Chapter Skim
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15 Tris Monochloropropyl Phosphates
15 Tris Monochloropropyl Phosphates
Pages 338-357
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From page 338... ...
Variations in manufacturing methods result in commercial formulations that contain different proportions ofthe four TMCPPs listed in Table ~ 5- l . Mixtures in which the linear forms are above trace levels tend to be pale yellow; other mixtures are colorless (Albright and Wilson 1980a; Courtaulds Chemicals 1988~.
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phosphate] Synonyms 13674-84-5: TSCA Interagency tris(2-chloroisopropyl)
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All TMCPP toxicity testing has been carried out on commercial mixtures containing variable amounts of TMCPP isomers, which in addition to those previously mentioned, include bis(~-chloro-2-isopropyl) (2-chloropropyl)
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From page 341... ...
in olive oil, to groups of three to five mate Wistar rats. Absorption was calculated from the radioisotopic measurements of cumulative urinary excretion and cumulative exhalation (performed for 3 or 4 fit post-administration)
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Studies were not done according to GEP guidelines unless noted in the text. Dermal Exposure Irritation A product safety data sheet published by Couraulds specifically warns that skin irritation may result from prolonged contact with liquid TMCPP (Courtaulds Chemicals 19881.
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Systemic Effects Acute dermal toxicity studies were conducted on two different production batches of the TMCPP flame retardant Antiblaze~) 80 (Albright and Wilson 198Oa)
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Other Systemic Effects No studies were located that investigated the sensitization, immunological, neurological, reproductive, developmental, or carcinogenic effects of TMCPPs following dermal exposure. Inhalation Exposure Systemic Effects In an acute inhalation study, five male and five female Sprague-Dawley rats were exposed (whole-body)
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345 On Cal o o sit o ._ EM o Cal ._ .~ EM $ 4 Ct U)
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administered a single dose of TMCPPs in corn oil by gavage to mate and female Wistar rats (200, or 500 mg/kg for mates; only 2,000 mg/kg in females) and found that at or below 500 mg/kg, animals exhibited no clinical signs of toxicity over the subsequent 2-wk observation period.
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347 Cal of ~ of b4.~ .= =3 _ ma U
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348 it> c: U
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(1982) gave groups of five female Wistar rats a single dose of 945, 1,137, 1,349, 1,633, 2,000, or 2,400 mg/kg of TMCPPs by Savage in olive oil.
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Other Systemic Effects No studies were located that investigated immunological effects to TMCPPs following oral exposure. 2Doses calculated from the following values reported by the authors: total 21-d intake, total body weight gain, and the initial average body weight of the females used for toxicity tests, described in Section 4.1.1; (21-d mg "TMCPPs"~/21 d = mg "TMCPPs"/d divided by the time-weighted average body weight in kg)
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TMCPPs (TCIP, CASRN 13674-84-5) , at concentrations ranging from 0 to I ,000,ug/plate, yielded negative results in mutagenicity tests using Salmonella typhimurium strains TA97, TA98, TAl00, TAl535, and TAl537, with or without metabolic activation (Zeiger et al.
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Insufficient data are available for deriving a dermal or oral RfD for TMCPP. Therefore, no conclusions can be drawn concerning the noncancer health risks associated with dermal exposure to TMCPP in furniture upholstery.
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Therefore, no conclusions can be drawn about the noncancer health risks posed by the inhalation of TMCPP vapors. Oral Exposure The assessment of noncancer toxicological risk for oral exposure to TMCPP is based on the oral exposure scenario described in Chapter 3.
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The subcommittee recommends that the potential for release of TMCPP vapor into air and TMCPP released into saline from treated fabric be investigated. REFERENCES Akzo Nobel.
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1996. Tris(2-chlorisopropyl~phosphat (13674-84-5~: Acute Oral Toxicity Study in Male and Female Wistar Rats.
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Consumer Product Safety Commission, Washington, DC. TSCA Interagency (Toxic Substances Control Act Interagency Testing Committee)
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