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Glossary
Pages 337-344

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From page 337...
... Benchmark dose analysis - A technique for quantitative assessment of noncancer health effects. Benchmark dose - An exposure level that corresponds to a statistical 337
From page 338...
... or the product of interactions between a xenobiotic agent and some target molecule or cell that is measured in a compartment within an organism. Biologically effective dose - The amount of the deposited or absorbed contaminant that reaches the cells or target site where an adverse effect occurs or where an interaction of that contaminant with a membrane surface occurs.
From page 339...
... - A factor that is associated Faith both the exposure and outcome of interest and can distort the annar~nt magnitude of the effect of the study factor. -err A ~~ Developmental toxicity - The occurrence of adverse effects on the developing organism that may result from exposure to a chemical prior to conception (either parent)
From page 340...
... Half-Life - The time required for the elimination of half a total dose from the body. Human health risk assessment - A process used to estimate the likelihood of adverse health outcomes of environmental exposures to chemicals.
From page 341...
... Lowest-observec3-aciverse-effect level (LOAEL) - The lowest exposure level at which there are statistically or biologically significant increases in frequency or severity of adverse effects between the exposer!
From page 342...
... that is likely to be without an appreciable risk of deleterious effects during a lifetime. Reproductive toxicity - The occurrence of adverse effects on the reproductive system that may result from exposure to a chemical.
From page 343...
... Chronic toxicity is the ability of a substance or mixture of substances to cause harmful effects over an extended period, usually upon repeated or continuous exposure sometimes lasting for the entire life of that exposed organism. Subchronic toxicity is the ability of the substance to cause effects for more than one year but less than the lifetime of the exposed organism.
From page 344...
... Weight of the scientific evidence - Considerations involved in assessing the interpretation of published scientific information quality of methods, ability of a study to detect adverse effects, consistency of results across studies, and biological plausibility of cause-and-effect relationships.


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