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3 Other Related Health-Hazard Assessment Processes
Pages 37-44

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From page 37...
... The information contained in this section was derived from material provided by major consumer product and pharmaceutical companies (Lilly Research laboratories, Wolf (1987) , Boylstein et al (unpublished)
From page 38...
... It provides the responsible toxicolog~st or industrial hygienist conducting the risk assessment win a system for evaluating available toxicity information and identifying data gaps. Once the health risk assessment report is completed, it goes to a re
From page 39...
... That information is updated on a regular basis and available electronically by readaccess at all sites globally. The risk-assessment specialist takes advantage of available electronic databases to obtain the best information possible for conducting health risk assessments.
From page 40...
... Mechanistic Approach _| Revise Guideline Obtain More Data, e.g., from Inhalation Studies , FIGURE 3-1 Typical decision tree for performing toxicological risk assessment (figure provided by R.K. Wolff, Lilly Research Laboratories)
From page 41...
... into the health hazard assessment process to verify the original decisions made on protective equipment and to aid in designing safety standards for new processes (O'Donoghue 1989~.
From page 42...
... The Peer Review Board meets twice yearly to examine progress on outstanding issues, review current and planned work, provide guidance on breaking issues in the field, suggest problem resolutions, and identify useful resources and procedures for data collection and evaluation. Membership is comprised primarily of doctorate-level toxicologists with expertise in industrial toxicology, forensic toxicology, clinical toxicology, pathology, quantitative risk assessment, emergency-response planning, risk communication, analytical chemistry, preventive medicine, toxicolog~cal information storage and retrieval systems, and industrial chemical registration and preparation of health-hazard assessments under OSHA and international workplace standards.
From page 43...
... Environmental Protection Agency inspections; · maintain copies of all protocols pertaining to toxicological studies for which the QAO is responsible; · inspect toxicological studies at intervals to ensure study integrity; · maintain records of inspections and report their results to management; · review final study reports to ensure that reported results are accurately reflected; and · maintain SOPs describing the functions and responsibilities of the QAO. The QAO coordinator periodically reports to the Peer Review Board on the status of GAP compliance in the CHPPM Directorate of Toxicology.
From page 44...
... Toxicity-evaluation staff within the Directorate identify chemical hazards and perform toxicity evaluations to develop preventive procedures for avoiding or minimizing hazardous exposures. Computerized databases, literature surveys, laboratory studies, and consultations with other health care advisors are all employed to accomplish individual assessments.


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