Gulf War and Health Volume 1: Depleted Uranium, Sarin, Pyridostigmine Bromide, and Vaccines (2000) / Chapter Skim
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Appendix E: Effects of Long-Term Exposure to Organophosphate Pesticides in Humans
Appendix E: Effects of Long-Term Exposure to Organophosphate Pesticides in Humans
Pages 366-377
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From page 366... ...
Second, OP pesticide exposures are much more common than sarin exposure, yielding greater evidence for examining potential health effects. There are about 10,000 cases of OP pesticide poisoning in the United States each year (cited in Steenland et al., 1994~.
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From page 367... ...
Table E.2 summarizes 10 studies, one of which is also included in Table E.1, that provide evidence of the longer-term health effects of chronic exposure to OP pesticides at levels insufficient to cause acute effects. Nearly all such studies are cross sectional, observational studies, which by nature are subject to common epidemiologic biases, including selection bias and reporting or information bias (see Chapter 3)
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From page 368... ...
In summary, the available literature indicates that exposure to OP pesticides at levels sufficient to cause acute health effects requiring medical reporting or treatment is associated with elevated rates of neurological or psychiatric symptoms and poorer performance on standardized neuropsychological tests several years after the acute exposure.
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From page 369... ...
is also included in the previous section. The health outcomes in the eight cross sectional and one longitudinal study include neurological symptoms, neuropsychological tests, and psychiatric; symptoms.
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370 Cal a' U)
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From page 375... ...
In summary, the extensive epidemiological evidence on the association of OP pesticide exposure and adverse health effects is consistent with and supports the more limited evidence on human exposure to sarin described in Chapter 5. There is consistent evidence that OP pesticide exposures sufficient to produce acute symptoms requiring medical care or reporting are associated with longerterm (1-10 years)
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From page 376... ...
1998. Effects of long-term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers.
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From page 377... ...
APPENDIX E 377 Stephens R Spurgeon A, Calvert IA, Beach J
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