Biographical Memoirs Volume 78 (2000) / Chapter Skim
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Robert Cooley Elderfield
Robert Cooley Elderfield
Pages 1-15
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13io,qraphicat Memoirs VOLUME 78
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Together with his students at Columbia University en c! later at the University of Michigan, he workocl on alkaloicis, proviclecl the best synthetic routes to the effective antimalarial pamaquine, examiner!
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Cooley, Dean of the Engineering School of the University of Michigan, Robert cleciclecl to attend a small liberal arts college, Williams College, before going to MIT for gracluate work. To satisfy the entrance requirements for Williams, particularly insofar as Latin was concerned, he returned to Choate for a second year, completing that requirement en cl accumulating consiclerable acivancec!
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inclivicluals who were connecter! with the chemical industry that was then concentrated in the Niagara Falls region.
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5 I, National Academy Press, ~ 980) the amusing account of the successful clegraciation of a cligitoxigenin derivative to etiocholanic acid for structural correlation.
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Once, when I was having trouble purifying reaction intermediates, he zipped through a four-step sequence on a one-mole scale cluring two evening sessions. Center cuts of the liquicis hacl perfect elemental analyses, en c!
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Elclerfielcl's research at Columbia University incluclecl the subject of alkaloicis with which he hacl become familiar while at Rockefeller University. His investigation of the cardiac aglycones was extenclecl to inclucle final structure verification and synthesis of model unsaturated lactones related to the aglycones.
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With his Michigan students he initiates! research on novel anionic aromatic substitution reactions en cl engaged in an ambitious program on potential anticancer agents.
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incluclecl a section on his importance to his colleagues: As well as a superb scholar, Professor Elderfield was a tower of academic and personal strength for his colleagues, particularly the younger ones, and many of the now older members of faculty remember his support with gratitude. Whatever he did, Bob Elderfield did well.
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Bob took great pricle in the accomplishments of his students graduates, unclergracluates, en cl postdoctorates en cl never forgot that students are an important product of university research. AM MOST GRATEFUL to Bob s family his daughters, Nancy and Margaret Helen, and his sister, Esther and to Bob's Michigan colleagues, especially Martin Stiles, for the information they provided.
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Studies on lactones related to the cardiac aglycones.
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Potential anticancer agents (I) Nitrogen mustards derived from p-tN,N-bis (2-chloroethyl~amino]
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Alstonia alkaloids.
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