Biographical Memoirs Volume 78 (2000) / Chapter Skim
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William D. Phillips
William D. Phillips
Pages 166-181
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From page 167... ...
He was in a physical chemistry laboratory that was trying to obtain vibrational en cl Raman spectra from biological molecules. At that time clifficulties arose from the impurities present in 167
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Bill's first publication out of du Pont, a single authored letter to the editor in the journal of Chemical Physics in 1955, clescribec! the use of OH NMR to demonstrate unequivocally the existence of restricted rotation in amides.
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by paramagnetic metal ions wouIcI, in time, become a powerful tool for structural eluciciation en cl a major focus of his research. He observed large shifts of proton resonances in alcohols complexecl with Co2+ (or Ni2+)
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a significant covalent contribution. In a series of papers in the 1960s, Bill Phillips en cl coworkers usecl isotropic contact proton hyperfine interactions to determine the configurations and magnetic properties of paramagnetic big-nickel (II)
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salicylalclimines. These finclings were parallel to NMR experiments I was cloing at Bell Telephone Laboratories on the i9F resonances in transition element fluorides en cl very clirectly relatecl to ESR experiments of the hyperfine interactions with protons of organic free raclicals clone in many laboratories but most significantly by Harden MacConnell.
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From page 172... ...
With the highest-frequency high-resolution NMR spectrometers and the newly available computer of average transients (CAT) , Bill Phillips with his long time collaborator C
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of information, particularly easy to obtain from NMR melting experiments dominates foIcling or melting ciata to this clay. In subsequent experiments, Bill en c!
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From page 174... ...
the 220MHz NMR spectra of several proteins, lysozyme, ribonuclease, cytochrome C, en cl Fe-S proteins as well as of nucleic acids. In previous high-resolution NMR studies of proteins at 100 MHz, Bill and others, particularly Oleg Jardetzky, hacl shown some well-resolvecl lines that were separated by interaction with their unique environment from the broac!
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From page 175... ...
home to Bell Telephone Laboratories to report Bill's results, a story so convincing that Bell Labs authorized us within 10 clays to order the second 220MHz spectrometer. Bill Phillips's 220-MHz spectra were one of the eye openers of my scientific life.
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From page 176... ...
Moving to Washington, D.C., he chaired the National Critical Technologies Panel, whose first biennial report, presented to President Bush in 1991, became a blueprint for government action. In clear, lucicI, direct prose the report convincingly acivocatecl enhancing en cl securing for the Unitecl States those technologies they iclentifiec!
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exploring a new part of the worIcI. A similar gentle acceptance permeates!
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In no case was it a harsh world, nor a strongly challenging environment, but both to science and to administration Bill Phillips brought a similar sense. They were part of a fine enterprise, they reached out to worthwhile goals, and he could do his share.
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Penman. Nucleic acids: A nuclear magnetic resonance study.
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Lazar. Nuclear magnetic resonance determination of thymine nearest neighbor base frequency ratios in deoxyribonucleic acid.
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From page 181... ...
Zand. The solution behavior of the bovine myeline basic protein in the presence of the anionic ligands.
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