Veterans and Agent Orange Herbicide/Dioxin Exposure and Type 2 Diabetes (2000) / Chapter Skim
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Pages 36-44
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From page 36... ...
found positive but non-statistically significant associations between measures of exposure and notations of diabetes on death certificates, although the later paper also found a significant negative trend between diabetes mortality and cumulative TCDD exposure. The fourth study, which examined workers in 12 countries who produced or sprayed phenoxy herbicides and chlorophenols (including some of those investigated by Steenland and colleagues)
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The primary analysis in the Air Force Health Study (AFHS, 2000) showed nearly identical diabetes incidence in Ranch Hand veterans and the matched comparison group.
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Three recent studies of humans reviewed here add to that evidence by reporting a compensatory metabolic relation between dioxin and insulin regulation in Air Force Health Study participants (Michalek et al., 1999) , an apparent association between serum dioxin levels and fasting glucose levels among nondiabetic AFHS comparison group members with less than 10 ppt serum dioxin (Longnecker and Michalek, 2000)
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1985. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides.
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Part I A Retrospective Cohort Study of Mortality Among Australian National Servicemen of the Vietnam Conflict Era, and an Executive Summary of the Mortality Report.
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1997. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand.
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1999. Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand.
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1995. Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand.
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1995. Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand.
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