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Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
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Appendix B
Issues of Resistance: Microbes, Vectors, and the Host

February 6–7, 2002

Lecture Room

National Academy of Sciences

2101 Constitution Avenue, NW

Washington, DC 20418

AGENDA

WEDNESDAY, FEBRUARY 6, 2002

**** A PUBLIC DISSEMINATION PANEL DISCUSSION OF THE BIOLOGICAL THREATS REPORT will take place from 9:00–10:00 am. Breakfast will be served. ****

10:30 am

Welcome and Opening Remarks

Adel Mahmoud, Chair, Forum on Emerging Infections President, Merck Vaccines

10:45

Arms Races with Evolving Diseases: Patterns, Costs and Containment

Stephen Palumbi, Harvard University

Session I: Case Studies of Antimicrobial Resistance

Moderator: Carlos Lopez, Eli Lilly

11:15

The Cost of Antimicrobial Resistance

Richard Smith, University of East Anglia, United Kingdom

11:45

Resistant Strains of Pneumococci, Staphylococci, and Enterococci

Alexander Tomasz, Laboratory of Microbiology, Rockefeller University

12:15 pm

LUNCH

Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×

1:30

Resistance to HIV-1 Drug Therapies

Robert Redfield, The Institute of Human Virology, University of Maryland

2:00

Chloroquine-Resistant Malaria

Thomas Wellems, National Institute for Allergy and Infectious Diseases, NIH

2:30

Schistosomiasis and Antihelminth Resistance

Charles King, Division of Geographic Medicine, Case Western Reserve University

3:00

Epitope Escape Variants

Robert Webster, St. Jude Children’s Research Hospital and World Health Organization Collaborating Center for Studies on the Ecology of Influenza in Animals and Birds

Session II: Vector Resistance

Moderator: Barry Beaty, Colorado State University

3:30

Pesticide Resistance: Implications for Disease Emergence and Control

Janet Hemingway, Liverpool School of Tropical Medicine, United Kingdom

4:00

Studies in Antibiotic Resistance and Insecticide Resistance: Commonalties, Differences, and New Directions

Steven Peck, Zoology Department, Brigham Young University

4:30

Managing the Emergence of Pesticide Resistance in Disease Vectors

William Brogdon, Division of Parasitic Diseases, Centers for Disease Control and Prevention

Session III: Discussion Panel

Moderator: Carole Heilman, National Institute for Allergy and Infectious Diseases

5:00

William Jack, Georgetown University

Lynn Marks, GlaxoSmith Kline

Steve Brickner, Pfizer

6:00

Adjournment of the first day

6:15

DINNER MEETING OF THE FORUM ON EMERGING INFECTIONS

Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×

THURSDAY, FEBRUARY 7, 2002

8:30 am

Continental Breakfast

9:00

Opening Remarks / Summary of Day 1

Stanley Lemon, Vice Chair, Forum on Emerging Infections Dean of Medicine, The University of Texas Medical Branch, Galveston

9:15

Antibiotic Resistance 1992–2002: A Decade’s Journey

Stuart Levy, School of Medicine, Tufts University

Session IV: Factors of Emergence

Moderator: Mary Wilson, Harvard University

9:45

Patterns of Use for Antimicrobials in Developing Countries

Iruka Okeke, University of Bradford, United Kingdom

10:15

Health Care-Acquired Infections: Hospitals and Long-Term Care Facilities as Breeding Grounds for Antimicrobial Resistance

Lindsay Nicolle, University of Manitoba, Canada

10:45

The Use of Antimicrobials in Food-Producing Animals

Thomas Shryock, Elanco Lilly Research

11:15

Special Considerations: Anthrax, Large-Scale/Long-Term Prophylaxis or Therapy and the Emergence of Microbial Resistance

Thomas Elliott, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences

Session V: Containing the Development of Resistance

Moderator: James Hughes, Centers for Disease Control and Prevention

11:45

Emergence of Multiple Mechanisms of Resistance to Antibacterials

Shahriar Mobashery, Department of Biochemistry, Wayne State University

12:15 pm

Emerging Technologies to Combat Resistance: Opportunities and Limitations

Vincent Fischetti, Laboratory of Bacterial Pathogenesis, Rockefeller University

12:45

LUNCH

Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×

1:30

Interagency Action Plan to Combat Antimicrobial Resistance

David Bell, National Center for Infectious Diseases, Centers for Disease Control and Prevention

Murray Lumpkin, Office of the Commissioner, Food and Drug Administration

2:15

Using Pharmacokinetics and Pharmacodynamics to Manage Resistance in the Hospital, at the Bedside, and in Drug Development

Jerome Schentag, University at Buffalo School of Pharmacy

2:45

FDA Regulatory Approaches to Controlling Antimicrobial Resistance

Mark Goldberger, Center for Drug Evaluation and Research, Food and Drug Administration

3:15

CDC’s 12-Step Program to Address Antimicrobial Resistance

Julie Gerberding, National Center for Infectious Diseases, Centers for Disease Control and Prevention

3:45

The Challenges to Implementing Global Policy for the Control of Antimicrobial Resistance

Anthony Savelli and Terry Green, Management Sciences for Health

4:15

BREAK

Session VI: Priorities for the Next Steps in Addressing Resistance

Moderator: Fredrick Sparling, University of North Carolina, Chapel Hill

4:30

With the backdrop of the previous days’ presentations and discussion, Forum members, panel discussants, and the audience will comment on the issues and next steps that they would identify as priority areas for consideration within industry, academia, public health organizations, and other government sectors. The discussion of priorities will summarize the issues surrounding emerging opportunities for more effective collaboration as well as the remaining research and programmatic needs. The confounding issues of the major obstacles to preparing an optimal response, particularly as it relates to the complexities of interaction between private industry, research and public health agencies, regulatory agencies, policymakers, academic researchers, and the public will be explored with an eye toward innovative responses to such challenges.

Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×

Panel Discussants:

 

Ramanan Laxminarayan, Resources for the Future

Mary Torrence, U.S. Department of Agriculture, Cooperative State Research Education and Extension Service

Donald Roberts, Uniformed Services University of the Health Sciences

5:30

Adjourn

Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×
Page244
Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×
Page245
Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×
Page246
Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×
Page247
Suggested Citation:"Appendix B: Agenda: Issues of Resistance: Microbes,Vectors, and the Host." Institute of Medicine. 2003. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10651.
×
Page248
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The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.

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