Summary tables of biological tests: Volume 5 No. 4 : August 1953 (1953)

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-^84- TABLE V TOXICm TESTS Screening Agency: Sloan-Kettering I n s t i t u t e for Cancer Reseaich, New York, New York Technique: Adult mice given intraperitoneal i n j e c t i o n of a constant volume of solutions or suspensions of each compound not to exceed 0.5 ml, A single dose i s given. The weight response i s deteriiuned by a comparison of the weight on the t h i r d or fourth day afte r adiLinis- t r a t i o n with the weight at the time of administration. Tlie anuaals are observed for a t o t a l of seven days. This t e s t i s a routine procedure for estimating a chronic dose for the Sarcoma 180 assayo CBC No. 402,647 (57) 900,235 (11) 904,406 (60) Name and Structure Acetbphenone, a-chloro- a-phenyl- < ^ > C 0 G K ( C 1 ) < ^ ) Anthranilic acid, 3,5- dichloro- COOH Dose Benzene^ulfonamide, £-( diethylbriazeno)- (CgH^)2NN=N<^S02NHg Mortality ' » Day of'Death 500 mg/kg 2/5 3, 7 Solvent: 1/2^ car b o y methyl cel l u l o s e i n isotonic s a l i n e 500 mg/kg 4/4 25 min .(3); 45 min. 250 0/3 125 0/3 62,5 0/3 31.3 0/3 Solvent: 1/2^ carboxy methyl cellulose i n isotonic saline 500 mg/kg 0/5 Solvent: l/2/S carboay methyl cellvilose i n isotonic saline 904,281 Benzoic acid, 6-benzoyl- (57) 3-chloro-2-nitro* 500 mg/kg 1/5 2 Solvent: 1/2^ carboxy methyl c e l l u l o s e i n isotonic s a l i n e 507,188 Benzoic acid, 2-hydroxy- (57) mercuri-3-nitro-, 1,2-cyclic anhydride k>>-Hg- NO, 500 mg/kg 5/5 1, 1, 1, 1, 1 250 3/3 3, 3, 3 125 3/3 3, 3, 3 62.5 3/3 3, 3, 3 31c3 1/3 5 1st . dosage s e r i e s exhibited stretching Solvent; 1/2^ carboxy methyl cellulose i n isotonic s a l i n e

-285- TOXICITT TESTS (Continued) CBC No. Name and Structure 507,050 (57) 904,278 (57) 4,4' -Bipheryldicarboxylic acid, 2,2»-dinitro-, diethyl e s t e r °29- / ^^COOCgH^ C.H-OOC 3,3'-Bipheryldisulfonic a;cid, 4,4'-diamine- HO^S 506,708-15 d-Camphcr, 3-amino-. (57) monies a"'1 a V; ;h. CH,XCH, SO. Dose Mortality Day of Death 500 mg/kg 0/5 Solvent: 1/2^ earboxy methyl c e l l u l o s e i n isotonic s a l i n e 500 mg/kg 0/5 Solvent; 1/2^ carboxy methyl cellulose i n isotonic saline 500 mg/kg 0/5 Exhibited a t a x i a Solvent: isotonic saline 904,280 Capi-cic acid, C-benzamido- (57) a-bromo- ^_J^CONH( CHg )^CH( Br ) COOH 500 mg/kg 0/5 Solvent: 1/2^ carbojjy methyl c e l l u l o s e i n isotonic s a l i n e 506,704 (57) 402,504 (57) 402,634 (57) Caprylic acid, a-amino- CH3(CHg)^CH(NHg)C0OH Chaleone, 3-chloro- < ^ C O C H = C H < ^ ^^^^^ CI Cinnamie acid, o-fluoro- F ^^CH=CHCOOH 500 mg/kg 0/5 Solvent: 1/2^ oarboxy methyl c e l l u l o s e i n isotonic s a l i n e 500 mg/kg 0/5 Solvent: 1/2^ carboxy methyl c e l l u l o s e i n isotonic s a l i n e 500 mg/kg 0/5 Solvent: l/Z% carbojy methyl c e l l u l o s e i n isotonic s a l i n e

-286- TOXICITy CBC No. 506,718 (46) 506,714 (46) 400,866 (56) 400,726 (61) (33) 5KO,102 (2) TESTS (Continued) Name and Structure Crotonanilide, N-sec-butyl- 2" (sec-butylamino)- Cll3CHgCH(CH3)NCOCH=CHCH3 ^^Cn(CH3)CHgCH3 m-Crotonotoluidide, N-ethyl- PCHgCH3 NC0CH=CHCH3 Ethanol, 2 , 2 ' - s u l f i n y l d i - (H0CH2CHg)gS0 E t h y l phosphite, t r i - Dose Mortality Day of Death 500 mg/kg 1/5 3 Elxhibited ataxia and depression Solvent} l/Z% carboxy methyl c e l l u l o s e in isotonic s a l i n e 500 cmni/kg 4/5 25 i i i i n . ( l ) j 3, 7, 7 2, 3, 7 2, 7 7 250 3/3 125 2/3 62.5 1/3 31.3 0/3 1st. dosage s e r i e s exhibited ataxia; clonic movements, gasping Solvent: propylene gl y c o l , 500 mg/kg 0/5 Solvent: isotonic s a l i n e 500 cmo/kg 0/5 Solvent: propylene glycol Guanidine, 1-phenyl-, stearate 500 mg/kg 1/5 1 Solvent: 1/2^ carboxy methyl ce l l u l o s e i n isotonic s a l i n e (/_yNHC(:NH)NH2 • CH3(CH2)^^C00H 402,649 1,7-Heptanedion?, 2,6-dibromo- 500 mg/kg 4/5 3, 3, 7, 7 (57) 1,7-diphenyl- 250 0/3 125 0/3 62.5 0/3 Solvent: l/Z% carboxy methyl ce l l u l o s e i n isotonic s a l i n e ^ ^ C O C H ( B r ) (CHg )3CH(Br) C O ^ ^ 802,670 (57) Homophthalonitrile CHgCN 500 mg/kg 0/5 Solvent: 1/2^ carboxy methyl c e l l u l o s e i n isotonic s a l i n e CN

-287- TOXIOITT TESTS (Continued) CBC No.> - Name and Structure I s a t i n , 7-methyl- i»0 507,199 (57) Co:: CH« Dose • .Mortality Day of Death 500 mg/kg 0/5 Solvent: 1/2^ carboxy methyl cellui.ose i n isotonic saline 904,283 2-Isoindolinemalonic acid, (57) a-(2,3-dibromopropyl)- 1,3-dioxo-, di e t h y l e s t e r 9 500 mg/kg 0/5 Solvent; \JZ% carboxy methyl c e l l u l o s e in' isotonic s a l i n e • NC(C0bCHgCH2)2CHgCHBrCHgBr -1=0 ^ra.,35^,^. Morpholine, 4-acetyl- 0 NCOCHg 500 cmVkg 0/5 Solvent: propylene glycol 904,^90 4-tiorphplin9phqsphonic acid, ' 5OO mg/kg 1/5 3 (4^) diphenyi e s t e r Solvent: isotonic s a l i n e 0 NP(:0) \ / 505,925 2,4-Oxazolidinedione, (57) . 5,5-dimethyl- J 2 500 mg/kg 0/5 Solvent: isotonic s a l i n e 506,716 (57) 0= l,10-Phenanthroline-3- c a r b o j y l i c a c i d , 4-hydrdxy- 5-metho:qr- 500 mg/kg 250' 125 62,5 31.3 15.6 3/3 1/3 0/3 0/3 0/2 3 h r s . (5) 1, 1, 1 1 Solvent: 1/2$ carboxy methyl ce l l u l o s e i n isotonic s a l i n e

-288- TOXICITY TESTS (Continued) CBC Noo Name and Structure Phenol, pentabromo-400,880 (11) 507,201 (57) OH B r | < ^ Br B r l ^ ^ Br Br Dose Moirtality 500 mg/kg 5/5 Day of Death 10 min. (4)i 20 min. 20 min., 1,1 250 3/3 125 0/3 62.5 0/3 31.3 0/3 SolvBBt: 1/2̂ 0 earboxy methyl cellulost i n isotonic saline Phthalamic ac i d , N,N-dimethyl- 500 mg/kg 0/5 Solvent: isotonic s a l i n e OCOOH C0N(CH2)g 507,056 Piperidine, l , l « - ( 2 , 2 ' - (46) dimethoxy-4,4'-biphenylene- b i s a z o ) d i - O CH3O OCH, 500 mg/kg 0/5 Solvent: 1/2̂ 5 earboxy methyl cellulose i n isotonic s a l i n e •N=NN 502,552 (47) 507,044 (46) Propionamide, a ,1̂ ' -dibutyl- CH^ ai2C0N(CHgCHgCHgCH^)^ Pyruvic a c i d , (£-nitro- phenyl)-, methyl ester CHgCOCOOCH 2 500 cmi^kg 250 ' 125 62.5 31.3 2/5 3/3 V3 0/3 0/3 1/2 nr. (2) 5,5,7 5 1 s t . dosage s e r i e s exhibited hyperpeaj strcub t a i l (occasional); gasping Solvent: propylene glycol 500 mg/kg 0/5 Solvent: 1/2^ earboxy methyl cellulose i n isotonic s a l i n e 802,877 (57) 508,091 (57) • Quinaldine, a-(£-bromo- benzylidene)- CH=CH^^~^Br N. 2 -(Shiinolinee t han o l r^>r%CHgCHgOH 500 mg/kg 0/5 Solvent: 1/2^ earboxy methyl c e l l u l o s e i n isotonic s a l i n e 500 mg/kg 1/5 7 Righting reflexes obtunded, pa r a l y s i s of limbs vdthin 1 min.j i n 30 mins. reflexes returned, but tremorous Solvent: l/2/o earboxy methyl eellvilose i n isotonic s a l i n e

-289- TOXICriY TESTS (Continued) CBC No. Name and Structure 9K0,019 (47) 402,632 (57) 802,997 (56) 904,274 (57) Quinoliniun compoxmd, 1-dodecyl— £-toluene sulfonate N VC3̂ "3 CH3(c1^)^ ' ^ 3- Thianaphthenol, 6-chloro. 4-methyl- Thiocyanic acid, diester vdth 2J£' -iminouiphenol NCS SCN m-Toluidine, 2,6-diiodo- 4-nitro- Dose Mortality Day of Death 500 mg/kg 5/5 1 h r . ( 4 ) j 2 h r s . 250- 3/3 1, 1, 1 125 3/3 1, 1, 1 62 o5 3/3 1, 1, 3 31.3 3/3 1, 1» 3 31.3 3/3 2 hrg,; 3, 3 15.6 • 3/3 3, 5, 5 7.8 3/3 3, 3, 5 3.9 2/3 3, 3 1.9 0/3 I Solvent: l/2Jg carboxy methyl cellulose i n isotonic s a l i n e 500 mg/kg 0/5 ' ' Solvent: 1/2^ carbdxy methyl cel l u l o s e i n isotonic s a l i n e 500 mg/kg 0/5 Solveht: 1/2^ carboxy methyl c e l l u l o s e i n isotonic s a l i n e 500 mg/kg 0/5 Solvent: 1/2^ carboxy methyl cel l u l o s e i n isotonic s a l i n e