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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Image

Accelerating the
Development and
Uptake of Rapid
Diagnostics to Address
Antibiotic Resistance

Erin Hammers Forstag and
Carolyn Shore, Rapporteurs

Forum on Drug Discovery,
Development, and Translation

Forum on Medical and
Public Health Preparedness for
Disasters and Emergencies

Forum on Microbial Threats

Board on Global Health

Board on Health Sciences Policy

Health and Medicine Division

Proceedings of a Workshop

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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This activity was supported by contracts between the National Academy of Sciences and Administration for Children and Families (Contract No. HHSP233201400020B; Task Order No. 75P00120F37103); American Burn Association; American College of Emergency Physicians; American College of Surgeons-Committee on Trauma; American Hospital Association; American Red Cross; American Society of Tropical Medicine and Hygiene; Amgen Inc.; Association of American Medical Colleges; Association of Public Health Laboratories; Association of State and Territorial Health Officials; AstraZeneca; Biogen; Burroughs Wellcome Fund (Contract No. 1023129, 1022390); Centers for Disease Control and Prevention (Contract No. 75D30121F00095, 75D30121D11240; Task Order No. 75D30121F00001): National Center for Emerging Zoonotic Infectious Diseases; Council of State and Territorial Epidemiologists; Critical Path Institute; East West Protection LLC; EcoHealthAlliance; Eli Lilly and Company; Emergency Nurses Association; ExxonMobil Foundation; FasterCures, Milken Institute; Foundation for the National Institutes of Health; Friends of Cancer Research; Healthcare Ready; Infectious Diseases Society of America; Johnson & Johnson (Contract No. C2022024120); Medable; Merck & Co., Inc. (Contract No. APA-21-151620; Grant No. MEM-22-160471); National Association of Chain Drug Stores; National Association of County and City Health Officials; National Association of Emergency Medical Technicians; National Fire Protection Association; National Highway Traffic Safety Administration (Contract No. 693JJ922P000037); National Institutes of Health (Contract No. HHSN263201800029I; Task Order No. HHSN26300007, HHSN26300011, HHSN26300026): National Cancer Institute, National Center for Advancing Translational Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Office of the Director; New England Journal of Medicine; New Venture Fund (Contract No. NVF-NGDF-NAT10-Subgrant-017387-2022-04-01); Office of the Assistant Secretary for Preparedness and Response (Contract No. 75A50121P00089); Sanofi (Contract No. 70602577); Takeda; The MITRE Corporation; The Rockefeller Foundation; Trauma Center Association of America; Uniformed Services University of Health Sciences (Award No. HU00012210001); U.S. Agency for International Development (Grant No. 7200AA18GR00003); U.S. Department of Defense; U.S. Department of Homeland Security (Contract No. HSHQDC-17-A-B0001; Task Order No. 70RWMD21F00000031); U.S. Department of Veterans Affairs (Contract No. 36C25022C0273); U.S. Food and Drug Administration (Contract No. 1R13FD007302-01, 75F40120P00; Award No. 5R13FD006897-03). Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

International Standard Book Number-13: 978-0-309-70240-9
International Standard Book Number-10: 0-309-70240-2
Digital Object Identifier: https://doi.org/10.17226/27008

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Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating development and uptake of rapid diagnostics to address antibiotic resistance: Proceesings of a workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/27008.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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PLANNING COMMITTEE ON ACCELERATING THE DEVELOPMENT AND UPTAKE OF RAPID DIAGNOSTICS TO ADDRESS ANTIBIOTIC RESISTANCE1

KENT E. KESTER (Co-chair), Vice President, Translational Medicine, International AIDS Vaccine Initiative

BETSY WONDERLY TRAINOR (Co-chair), Alliance Director, Diagnostics, CARB-X

JOHN BILLINGTON, Head of Commercial Pipeline and Health Security Policy and Advocacy, GSK

CAREY-ANN BURNHAM, Chief Clinical Officer, Pattern Bioscience

PAUL EDER, Senior Scientific Officer, National Institute of Allergy and Infectious Diseases, NIH

DEBORAH HUNG, Associate Professor and Core Faculty Member, Harvard Medical School

AMANDA JEZEK, Senior Vice President of Public Policy and Government Relations, Infectious Diseases Society of America

ROBIN PATEL, Elizabeth P and Robert E Allen Professor of Individualized Medicine, Division of Clinical Microbiology, Mayo Clinic

RIBHI SHAWAR, Assistant Director, Division of Microbiology Devices, Center for Devices and Radiological Health, Food and Drug Administration

SUSAN VAN METER, President, American Clinical Laboratory Association

Health and Medicine Division Staff

JULIE LIAO, Forum Director

CAROLYN K. SHORE, Forum Director

LISA BROWN, Senior Program Officer

SCOTT WOLLEK, Senior Program Officer

BIANCA ESPINOSA, Associate Program Officer (from July 2022)

DEANNA GIRALDI, Associate Program Officer (until September 2022)

CLAIRE BIFFL, Research Associate

ASHLEY BOLOGNA, Senior Program Assistant (from July 2022)

MELVIN JOPPY, Senior Program Assistant

ANDREW M. POPE, Senior Director, Board on Health Sciences Policy (until June 2022)

___________________

1 The National Academies of Sciences, Engineering, and Medicine’s planning committees are solely responsible for organizing the workshop, identifying topics, and choosing speakers. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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CLARE STROUD, Senior Director, Board on Health Sciences Policy (from June 2022)

Consultant

ERIN HAMMERS FORSTAG, Science Writer

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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FORUM ON DRUG DISCOVERY, DEVELOPMENT, AND TRANSLATION1

GREGORY SIMON (Cochair), Kaiser Permanente Washington Health Research Institute and University of Washington

ANN TAYLOR (Cochair), Retired

CHRISTOPHER P. AUSTIN, Flagship Pioneering

LINDA BRADY, National Institute of Mental Health, NIH

JOHN BUSE, University of North Carolina, Chapel Hill School of Medicine

LUTHER T. CLARK, Merck & Co., Inc.

BARRY S. COLLER, The Rockefeller University

TAMMY R.L. COLLINS, Burroughs Wellcome Fund

THOMAS CURRAN, Children’s Mercy, Kansas City

RICHARD DAVEY, National Institute of Allergy and Infectious Diseases, NIH

KATHERINE DAWSON, Biogen

JAMES H. DOROSHOW, National Cancer Institute, NIH

JEFFREY M. DRAZEN, New England Journal of Medicine

STEVEN K. GALSON, Retired

CARLOS O. GARNER, Eli Lilly and Company

DEBORAH HUNG, Harvard Medical School

LYRIC JORGENSON, Office of Science Policy, NIH

ESTHER KROFAH, FasterCures, Milken Institute

LISA M. LaVANGE, University of North Carolina

ARAN MAREE, Johnson & Johnson

CRISTIAN MASSACESI, AstraZeneca

ROSS McKINNEY JR., Association of American Medical Colleges

JOSEPH P. MENETSKI, Foundation for the National Institutes of Health

ANAEZE C. OFFODILE II, University of Texas MD Anderson Cancer Center

SALLY OKUN, Clinical Trials Transformation Initiative

ARTI RAI, Duke University School of Law

MARK ROGGE, University of Florida

KLAUS ROMERO, Critical Path Institute

JONI RUTTER, National Center for Advancing Translational Sciences, NIH

SUSAN SCHAEFFER, Patients’ Academy for Research Advocacy

JOSEPH SCHEEREN, Retired

ANANTHA SHEKHAR, University of Pittsburgh

___________________

1 The National Academies of Sciences, Engineering, and Medicine’s forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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JAY SIEGEL, Retired

ELLEN V. SIGAL, Friends of Cancer Research

MARK TAISEY, Amgen Inc.

AMIR TAMIZ, National Institute of Neurological Disorders and Stroke, NIH

PAMELA TENAERTS, Medable

MAJID VAKILYNEJAD, Takeda

JONATHAN WATANABE, University of California Irvine School of Pharmacy and Pharmaceutical Sciences

ALASTAIR WOOD, Vanderbilt University

CRIS WOOLSTON, Sanofi

Forum Staff

CAROLYN K. SHORE, Forum Director

BIANCA ESPINOSA, Associate Program Officer (from July 2022)

DEANNA GIRALDI, Associate Program Officer (until September 2022)

ANDREW MARCH, Associate Program Officer

ASHLEY BOLOGNA, Senior Program Assistant (from July 2022)

MELVIN JOPPY, Senior Program Assistant

ANDREW M. POPE, Senior Director, Board on Health Sciences Policy (until June 2022)

CLARE STROUD, Senior Director, Board on Health Sciences Policy (from June 2022)

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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FORUM ON MEDICAL AND PUBLIC HEALTH PREPAREDNESS FOR DISASTERS AND EMERGENCIES1

SUZET MCKINNEY (Co-Chair), Sterling Bay

CRAIG VANDERWAGEN (Co-Chair), East West Protection, LLC

JOANNE ANDREADIS, Centers for Disease Control and Prevention

TOM COTTER, Healthcare Ready

BROOKE COURTNEY, U.S. Food and Drug Administration

CINNAMON DIXON, National Institute of Environmental Health Sciences

DAVID EISENMAN, University of California, Los Angeles

CARINA ELSENBOSS, National Association of County and City Health Officials

BRUCE EVANS, National Association of Emergency Medical Technicians

DAVID FERRARO, Society for Critical Care Medicine

PRITESH GANDHI, U.S. Department of Homeland Security

ASHA GEORGE, Bipartisan Commission on Biodefense

NATALIE GRANT, Administration for Children and Families

JANET HAMILTON, Council of State and Territorial Epidemiologists

DAN HANFLING, In-Q-Tel

DAVID (CHRIS) HASSELL, Administration for Strategic Preparedness and Response

JOHN HICK, Hennepin County Medical Center

THOMAS KIRSCH, Uniformed Services University of the Health Sciences

RICHARD KWOK, National Institute of Environmental Health Sciences

JAMES LAWLER, University of Nebraska Medical Center

NICOLETTE LOUISSAINT, Healthcare Distribution Alliance

FREDA LYON, Emergency Nurses Association

MONIQUE MANSOURA, The MITRE Corporation

BIRGITTE MESSERSCHMIDT, National Fire Protection Association

AUBREY MILLER, National Institute of Environmental Health Sciences

BARBARA MULACH, National Institute of Allergy and Infectious Diseases

IRA NEMETH, American College of Emergency Physicians

JOHN OSBORN, Mayo Clinic College of Medicine

TARA O’TOOLE, In-Q-Tel

ANDREW PAVIA, Infectious Diseases Society of America

LEWIS RADONOVICH, National Institute for Occupational Safety and Health

___________________

1 The National Academies of Sciences, Engineering, and Medicine’s forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
×

TERRY RAUCH, U.S. Department of Defense

SARA ROSZAK, National Association of Chain Drug Stores

COLLEEN RYAN, American Burn Association

ROSLYNE SCHULMAN, American Hospital Association

RICHARD SERINO, Harvard T.H. Chan School of Public Health

SCOTT SHONE, Association of Public Health Laboratories

BRANNON TRAXLER, Association of State and Territorial Health Officials

TENER VEENEMA, Johns Hopkins Bloomberg School of Public Health

JENNIFER WARD, Trauma Center Association of America

GAMUNU WIJETUNGE, Department of Transportation

MATTHEW WYNIA, University of Colorado, Denver

DAVID ZONIES, Committee on Trauma—American College of Surgeons

Forum Staff

LISA BROWN, Senior Program Officer

SCOTT WOLLEK, Senior Program Officer

SHALINI SINGARAVELU, Program Officer

MICHAEL BERRIOS, Research Associate

CLARE STROUD, Senior Director, Board on Health Sciences Policy

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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FORUM ON MICROBIAL THREATS1

PETER DASZAK (Chair), EcoHealth Alliance

KENT E. KESTER (Vice Chair), International AIDS Vaccine Initiative

EMILY ABRAHAM, Johnson & Johnson

KEVIN ANDERSON, Retired

DANIEL BAUSCH, American Society of Tropical Medicine and Hygiene

CHRISTOPHER BRADEN, Centers for Disease Control and Prevention

CRISTINA CASSETTI, National Institute of Allergy and Infectious Diseases, NIH

ANDREW CLEMENTS, U.S. Agency for International Development

MALICK DIARA, ExxonMobil

SCOTT F. DOWELL, Bill & Melinda Gates Foundation

MARCOS A. ESPINAL, Pan American Health Organization

EVA HARRIS, University of California, Berkeley

JON H. HEINRICHS, Sanofi

ELIZABETH D. HERMSEN, Pfizer Inc.

MARK G. KORTEPETER, Uniformed Services University of the Health Sciences

MICHAEL MAIR, U.S. Food and Drug Administration

JONNA MAZET, University of California, Davis

VICTORIA McGOVERN, Burroughs Wellcome Fund

SALLY A. MILLER, The Ohio State University

SUERIE MOON, The Graduate Institute of International and Development Studies, Geneva

RAFAEL OBREGON, United Nations Children’s Fund

KUMANAN RASANATHAN, World Health Organization

GARY A. ROSELLE, U.S. Department of Veterans Affairs

PETER A. SANDS, The Global Fund to Fights AIDS, Tuberculosis, and Malaria

THOMAS W. SCOTT, University of California, Davis

MATTHEW ZAHN, Orange Country Health Care Agency

Forum Staff

JULIE LIAO, Forum Director

LIZ ASHBY, Associate Program Officer

CLAIRE BIFFL, Research Associate

JUSTIN HAMMERBERG, Senior Program Assistant (until November 2022)

___________________

1 The National Academies of Sciences, Engineering, and Medicine’s forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Reviewers

This Proceedings of a Workshop was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published proceedings as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.

We thank the following individuals for their review of this proceedings:

CAROLE ANN BEWLEY, National Institute of Diabetes and Digestive Kidney Diseases, NIH

BRIAN RAUX, bioMérieux

ANTHONY SO, Johns Hopkins Bloomberg School of Public Health

Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the content of the proceedings, nor did they see the final draft before its release. The review of this proceedings was overseen by JIM E. RIVIERE, North Carolina State University. He was responsible for making certain that an independent examination of this proceedings was carried out in accordance with standards of the National Academies and that all review comments were carefully considered. Responsibility for the final content rests entirely with the rapporteurs and the National Academies.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Acknowledgments

Support from the sponsors of the Forum on Drug Discovery, Development, and Translation, the Forum on Medical and Public Health Preparedness for Disasters and Emergencies, and the Forum on Microbial Threats is crucial to support this and other work of the National Academies.

The National Academies’ staff wish to express their gratitude to the speakers whose presentations helped inform workshop discussions; to the members of the planning committee for their work in developing the workshop agenda and shaping the discussions; and to additional National Academies staff, without whom this workshop and the accounting thereof would not have been possible: Christie Bell, Samantha Chao, Robert Day, Rebekah Hanover Pettit, Benjamin Hubbert, Noah Ontjes, Devona Overton, Marguerite Romatelli, Bettina Seliber, Lauren Shern, Elizabeth Webber, and Taryn Young.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Page xvii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
×
Page xviii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
×
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
×
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
×

Acronyms and Abbreviations

ABC Acinetobacter calcoaceticus-baumannii complex
AI artificial intelligence
AMR antimicrobial resistance
ASSURED affordable, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable
AST antimicrobial susceptibility testing
ATTACK Acinetobacter Treatment Trial Against Colistin
BAA Broad Agency Announcement
BARDA Biomedical Advanced Research and Development Authority
BCID Blood Culture Identification
BEI Biological Exposure Indices
BIO Biotechnology Innovation Organization
BPP BIOFIRE® Pneumonia Panel
CAP Concept Acceleration Program
CARB-X Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator
CDC Centers for Disease Control and Prevention
C. diff Clostridioides difficile
CFUs colony-forming units
CLFS Clinical Laboratory Fee Schedule
CLIA Clinical Laboratory Improvement Amendments
CLSI Clinical and Laboratory Standards Institute
CMS Centers for Medicare & Medicaid Services
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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COVID-19 coronavirus disease 2019
CPT Current Procedural Terminology
CRE carbapenem-resistant Enterobacterales
DARPA Defense Advanced Research Projects Agency
DNA deoxyribonucleic acid
DRG Diagnosis Related Group
E. Coli Escherichia coli
ED emergency department
ESBL extended spectrum beta-lactamase
EU European Union
EUA Emergency Use Authorization
EUCAST European Committee on Antimicrobial Susceptibility Testing
FDA U. S. Food and Drug Administration
HHS Health and Human Services
IDEA Innovation + Design Enabling Access
IDSA Infectious Diseases Society of America
IRB institutional review board
IRS Internal Revenue Service
ITAP Independent Test Assessment Program
IV intravenous
LDTs laboratory developed tests
LMIC low- and middle-income countries
MALDI-TOF MSMatrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry
MAAP Mapping Antimicrobial Resistance and Antimicrobial Use Partnership
MDR multidrug resistant
MIPS Merit-Based Incentive Payment System
mNGS metagenomic next generation sequencing
MRSA methicillin-resistant Staphylococcus aureus
MSF Médecins Sans Frontières/Doctors Without Borders
MTB Mycobacterium tuberculosis
NG Neisseria gonorrhoeae
NGS next generation sequencing
Page xxiii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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NIAID National Institute of Allergy and Infectious Diseases
NIH National Institutes of Health (U.S.)
NLA National Limitation Amounts
NTAP new technology add-on payment
NWSS National Wastewater Surveillance System
OECD Organization for Economic Cooperation and Development
PACCARB Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria
PCR polymerase chain reaction
PCS Pre-Clinical Services
POC point-of-care
RADx Rapid Acceleration of Diagnostics
R&D research and development
RAPIDS GN Randomized Trial Evaluating Clinical Impact of Rapid Identification and Susceptibility Testing for Gram-negative Bacteremia
RCT randomized controlled trial
REASSURED real-time connectivity, ease of specimen, affordable, sensitive, specific, user-friendly, rapid, equipment-free, and deliverable
RIF rifampin
RSV respiratory syncytial virus
SALSA Saving Access to Laboratory Services Act
SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
STIs sexually transmitted infections
SUL-DUR sulbactam-durlobactam
UTI urinary tract infection
VA Department of Veterans Affairs
VRE Vancomycin-resistant enterococci
WHO World Health Organization
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2023. Accelerating the Development and Uptake of Rapid Diagnostics to Address Antibiotic Resistance: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27008.
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The use and misuse of antibiotics contributes to the rise in drug-resistant bacteria - a serious and worsening threat to human health. The development and use of rapid point-of-care diagnostics in the healthcare setting plays an important role in avoiding unnecessary use of antimicrobials by providing clinicians with the right information at the right time to help them make decisions about appropriate drug treatment for patients. Diagnostics also have the capacity to support early detection and diagnosis of drug-resistant bacterial infections, enable disease surveillance, and help prevent disease spread.

The National Academies Forum on Drug Discovery, Development, and Translation; Forum on Medical and Public Health Preparedness for Disasters and Emergencies; and Forum on Microbial Threats hosted an October 2022 workshop exploring the current landscape of rapid diagnostics to address antibiotic resistance, challenges and opportunities for spurring innovation, and practical next steps for accelerating the development of new diagnostic tools.

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