Arsenic in Drinking Water

National Research Council

doi:10.17226/6444

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Arsenic in Drinking Water

(1999)

The U.S. Environmental Protection Agency (EPA) has been considering a more stringent regulation of arsenic in water. A significant reduction in the maximum contaminant level (MCL) could increase compliance costs for water utilities. This book discusses the adequacy of the current EPA MCL for protecting human health in the context of stated EPA policy and provides an unbiased scientific basis for deriving the arsenic standard for drinking water and surface water.

Arsenic in Drinking Water evaluates epidemiological data on the carcinogenic and noncarcinogenic health effects of arsenic exposure of Taiwanese populations and compares those effects with the effects of arsenic exposure demonstrated in other countries—including the United States.

The book also reviews data on toxicokinetics, metabolism, and mechanism and mode of action of arsenic to ascertain how these data could assist in assessing human health risks from arsenic exposures. This volume recommends specific changes to improve the toxicity analyses and risk characterization. The implications of the changes for EPA's current MCL for arsenic are also described.

Contributor(s): National Research Council; Division on Earth and Life Studies; Commission on Life Sciences; Subcommittee on Arsenic in Drinking Water

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Suggested Citation

National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. https://doi.org/10.17226/6444.

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Publication Info

330 pages | 6 x 9 |

ISBNs:

Paperback: 978-0-309-06333-3
Ebook: 978-0-309-18401-4

DOI: https://doi.org/10.17226/6444

Chapters		skim
Front Matter	i-xx
Executive Summary	1-9
1 Introduction	10-15
2 The U.S. Environmental Protection Agency's 1988 Risk Assessment for Arsenic	16-26
3 Chemistry and Analysis of Arsenic Species in Water and Biological Materials	27-82
4 Health Effects of Arsenic	83-149
5 Disposition of Inorganic Arsenic	150-176
6 Biomarkers of Arsenic Exposure	177-192
7 Mechanisms of Toxicity	193-228
8 Variation in Human Sensitivity	229-250
9 Essentiality and Therapeutic Uses	251-263
10 Statistical Issues	264-298
11 Risk Characterization	299-301
Addendum to Chapter 9	302-306
Addendum to Chapter 10	307-310

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