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Enhancing NIH Research on Autoimmune Disease (2022)

Chapter: Appendix B: List of Autoimmune Diseases

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Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Appendix B

List of Autoimmune Diseases

Autoimmune Association Autoimmune Disease List (Autoimmune Association, 2021).

Achalasia

Addison’s disease

Adult Still’s disease

Agammaglobulinemia

Alopecia areata

Amyloidosis

Ankylosing spondylitis

Anti-GBM/Anti-TBM nephritis

Antiphospholipid syndrome

Autoimmune angioedema

Autoimmune dysautonomia

Autoimmune encephalitis

Autoimmune hepatitis

Autoimmune inner ear disease (AIED)

Autoimmune myocarditis

Autoimmune oophoritis

Autoimmune orchitis

Autoimmune pancreatitis

Autoimmune retinopathy

Autoimmune urticaria

Axonal & neuronal neuropathy (AMAN)

Baló disease

Behcet’s disease

Benign mucosal pemphigoid (Mucous membrane pemphigoid)

Bullous pemphigoid

Castleman disease (CD)

Celiac disease

Chagas disease

Chronic inflammatory demyelinating polyneuropathy (CIDP)

Chronic recurrent multifocal osteomyelitis (CRMO)

Churg-Strauss syndrome (CSS) or Eosinophilic granulomatosis (EGPA)

Cicatricial pemphigoid

Cogan’s syndrome

Page 454 Cite
Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Cold agglutinin disease

Complex regional pain syndrome (formerly known as reflex sympathetic dystrophy)

Congenital heart block

Coxsackie myocarditis

CREST syndrome

Crohn’s disease

Dermatitis herpetiformis

Dermatomyositis

Devic’s disease (neuromyelitis optica)

Discoid lupus

Dressler’s syndrome

Endometriosis

Eosinophilic esophagitis (EoE)

Eosinophilic fasciitis

Erythema nodosum

Essential mixed cryoglobulinemia

Evans syndrome

Fibromyalgia

Fibrosing alveolitis

Giant cell arteritis (temporal arteritis)

Giant cell myocarditis

Glomerulonephritis

Goodpasture’s syndrome

Granulomatosis with polyangiitis

Graves’ disease

Guillain-Barre syndrome

Hashimoto’s thyroiditis

Hemolytic anemia

Henoch-Schonlein purpura (HSP)

Herpes gestationis or pemphigoid gestationis (PG)

Hidradenitis suppurativa (HS) (Acne inversa)

IgA nephropathy

IgG4-related sclerosing disease

Immune thrombocytopenic purpura (ITP)

Inclusion body myositis (IBM)

Interstitial cystitis (IC)

Juvenile arthritis

Juvenile diabetes (Type 1 diabetes)

Juvenile myositis (JM)

Kawasaki disease

Lambert-Eaton syndrome

Lichen planus

Lichen sclerosus

Ligneous conjunctivitis

Linear IgA disease (LAD)

Lupus

Lyme disease chronic

Meniere’s disease

Microscopic polyangiitis (MPA)

Mixed connective tissue disease (MCTD)

Mucha-Habermann disease

Multifocal motor neuropathy (MMN) or MMNCB

Multiple sclerosis

Myasthenia gravis

Myelin oligodendrocyte glycoprotein antibody disorder

Myositis

Narcolepsy

Neonatal lupus

Neuromyelitis optica / devic disease

Neutropenia

Ocular cicatricial pemphigoid

Optic neuritis

Palindromic rheumatism (PR)

PANDAS (Pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections)

Paraneoplastic cerebellar degeneration (PCD)

Paroxysmal nocturnal hemoglobinuria (PNH)

Pars planitis (peripheral uveitis)

Parsonage-Turner syndrome

Pemphigus

Peripheral neuropathy

Perivenous encephalomyelitis

Pernicious anemia (PA)

POEMS syndrome

Polyarteritis nodosa

Page 455 Cite
Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Polyglandular syndromes type I, II, III

Polymyalgia rheumatica

Polymyositis

Postmyocardial infarction syndrome

Postpericardiotomy syndrome

Primary biliary cholangitis

Primary sclerosing cholangitis

Progesterone dermatitis

Progressive hemifacial atrophy (PHA) Parry Romberg syndrome

Psoriasis

Psoriatic arthritis

Pure red cell aplasia (PRCA)

Pyoderma gangrenosum

Raynaud’s phenomenon

Reactive arthritis

Relapsing polychondritis

Restless legs syndrome (RLS)

Retroperitoneal fibrosis

Rheumatic fever

Rheumatoid arthritis

Sarcoidosis

Schmidt syndrome or Autoimmune polyendocrine syndrome type II

Scleritis

Scleroderma

Sjögren’s Disease

Stiff person syndrome (SPS)

Susac’s syndrome

Sympathetic ophthalmia (SO)

Takayasu’s arteritis

Temporal arteritis/giant cell arteritis

Thrombocytopenic purpura (TTP)

Thrombotic thrombocytopenic purpura (Ttp)

Thyroid eye disease (Ted)

Tolosa-Hunt syndrome (THS)

Transverse myelitis

Type 1 diabetes

Ulcerative colitis (UC)

Undifferentiated connective tissue disease (UCTD)

Uveitis

Vasculitis

Vitiligo

Vogt-Koyanagi-Harada disease

Warm autoimmune hemolytic anemia

REFERENCES

Autoimmune Association. 2021. Autoimmune disease list. https://autoimmune.org/disease-information (accessed February 3, 2022).

Page 456 Cite
Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page 453 Cite
Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page 454 Cite
Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page 456 Cite
Suggested Citation:"Appendix B: List of Autoimmune Diseases." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Enhancing NIH Research on Autoimmune Disease
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Autoimmune diseases occur when the body's immune system malfunctions and mistakenly attacks healthy cells, tissues, and organs. Strong data on the incidence and prevalence of autoimmune diseases are limited, but a 2009 study estimated the prevalence of autoimmune diseases in the U.S. to be 7.6 to 9.4 percent, or 25 to 31 million people today. This estimate, however, includes only 29 autoimmune diseases, and it does not account for increases in prevalence in the last decade. By some counts, there are around 150 autoimmune diseases, which are lifelong chronic illnesses with no known cures. The National Academies of Sciences, Engineering, and Medicine was asked to assess the autoimmune disease research portfolio of the National Institutes of Health (NIH).

Enhancing NIH Research on Autoimmune Disease finds that while NIH has made impressive contributions to research on autoimmune diseases, there is an absence of a strategic NIH-wide autoimmune disease research plan and a need for greater coordination across the institutes and centers to optimize opportunities for collaboration. To meet these challenges, this report calls for the creation of an Office of Autoimmune Disease/Autoimmunity Research in the Office of the Director of NIH. The Office could facilitate NIH-wide collaboration, and engage in prioritizing, budgeting, and evaluating research. Enhancing NIH Research on Autoimmune Disease also calls for the establishment of long term systems to collect epidemiologic and surveillance data and long term studies (20+ years) to study disease across the life course. Finally, the report provides an agenda that highlights research needs that crosscut many autoimmune diseases, such as understanding the effect of environmental factors in initiating disease.

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