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Enhancing NIH Research on Autoimmune Disease (2022)

Chapter:Appendix E: Mission Statements of NIH's Institutes and Centers

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Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page487
Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page488
Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page489
Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page490
Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
×
Page491
Suggested Citation:"Appendix E: Mission Statements of NIH's Institutes and Centers." National Academies of Sciences, Engineering, and Medicine. 2022. Enhancing NIH Research on Autoimmune Disease. Washington, DC: The National Academies Press. doi: 10.17226/26554.
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Page492

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Appendix E Mission Statements of NIH’s Institutes and Centers IC Name IC Mission National Cancer The National Cancer Institute (NCI) leads, conducts, and supports Institute (NCI) cancer research across the nation to advance scientific knowledge and help all people live longer, healthier lives (NCI, 2018). National Eye The mission of the National Eye Institute (NEI) is to eliminate vision Institute (NEI)  loss and improve quality of life through vision research. To achieve this mission, NEI provides leadership to drive innovative research to un- derstand the eye and visual system, prevent and treat vision diseases, and expand opportunities for people who are blind or require vision rehabilitation; foster collaboration in vision research and clinical care to develop new ideas and share knowledge across other fields; recruit, inspire, and train a talented and diverse new generation of individu- als to expand and strengthen the vision workforce; educate health care providers, scientists, policymakers, and the public about advances in vision research and their impact on health and quality of life (NEI, 2021). National Heart, The National Heart, Lung, and Blood Institute (NHLBI) provides Lung, and Blood global leadership for a research, training, and education program Institute (NHLBI) to promote the prevention and treatment of heart, lung, and blood disorders and enhance the health of all individuals so that they can live longer and more fulfilling lives (NHLBI, 2014). 485 PREPUBLICATION COPY—Uncorrected Proofs

486 ENHANCING NIH RESEARCH ON AUTOIMMUNE DISEASE IC Name IC Mission National Human As a leading authority in the field of genomics, the mission of the Genome Research National Human Genome Research Institute (NHGRI) is to acceler- Institute (NHGRI)  ate scientific and medical breakthroughs that improve human health. NHGRI does this by driving cutting-edge research, developing new technologies, and studying the impact of genomics on society (NHGRI, 2018). National Institute The mission of the National Institute on Aging (NIA) is to support and on Aging (NIA) conduct genetic, biological, clinical, behavioral, social, and economic research on aging; foster the development of research and clini- cian scientists in aging; provide research resources, and disseminate information about aging and advances in research to the public, health care professionals, and the scientific community, among a variety of audiences (NIA, 2021). National Institute The mission of the National Institute on Alcohol Abuse and Alcohol- on Alcohol Abuse ism (NIAAA) is to generate and disseminate fundamental knowledge and Alcoholism about the effects of alcohol on health and well-being, and apply that (NIAAA) knowledge to improve diagnosis, prevention, and treatment of alcohol- related problems, including alcohol use disorder, across the lifespan (NIAAA, 2021). National Institute The National Institute of Allergy and Infectious Diseases (NIAID) con- of Allergy and In- ducts and supports basic and applied research to better understand, fectious Diseases treat, and ultimately prevent infectious, immunologic, and allergic (NIAID) diseases. For more than 60 years, NIAID research has led to new therapies, vaccines, diagnostic tests, and other technologies that have improved the health of millions of people in the United States and around the world (NIAID, 2021). National Institute The mission of the National Institute of Arthritis and Musculoskeletal of Arthritis and and Skin Diseases (NIAMS) is to support research into the causes, Musculoskeletal treatment, and prevention of arthritis and musculoskeletal and skin and Skin Diseases diseases; the training of basic and clinical scientists to carry out this (NIAMS) research; and the dissemination of information on research progress in these diseases (NIAMS, 2021). National Institute The mission of the National Institute of Biomedical Imaging and Bioen- of Biomedical gineering (NIBIB) is to improve health by leading the development and Imaging and accelerating the application of biomedical technologies. The Institute is Bioengineering committed to integrating engineering and physical sciences with biol- (NIBIB) ogy and medicine to advance our understanding of disease and its pre- vention, detection, diagnosis, and treatment. NIBIB supports emerging technology research and development within its internal laboratories and through grants, collaborations, and training (NIBIB, 2021). PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX E 487 IC Name IC Mission Eunice Kennedy The mission of the Eunice Kennedy Shriver National Institute of Child Shriver National Health and Human Development (NICHD) is to lead research and Institute of Child training to understand human development, improve reproductive Health and Hu- health, enhance the lives of children and adolescents, and optimize man Development abilities for all (NICHD, 2019). (NICHD) National Institute Established in 1988, the National Institute on Deafness and Other on Deafness and Communication Disorders (NIDCD) is mandated to conduct and Other Communi- support biomedical and behavioral research and research training in cation Disorders the normal and disordered processes of hearing, balance, taste, smell, (NIDCD) voice, speech, and language. The institute also conducts and supports research and research training related to disease prevention and health promotion; addresses special biomedical and behavioral problems associated with people who have communication impairments or disorders; and supports efforts to create devices that assist individuals with hearing loss or other communication disorders (NIDCD, 2019). National Institute The mission of the National Institute of Dental and Craniofacial Re- of Dental and Cra- search (NIDCR) is to advance fundamental knowledge about dental, niofacial Research oral, and craniofacial (DOC) health and disease and translate these (NIDCR) findings into prevention, early detection, and treatment strategies that improve overall health for all individuals and communities across the lifespan (NIDCR, 2018). National Institute The mission of the National Institute of Diabetes and Digestive and of Diabetes and Kidney Diseases (NIDDK) is to conduct and support medical research Digestive and and research training and to disseminate science-based information Kidney Diseases on diabetes and other endocrine and metabolic diseases; digestive (NIDDK) diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve people’s health and quality of life (NIDDK, 2021). National Institute The mission of National Institute on Drug Abuse (NIDA) is to advance on Drug Abuse science on the causes and consequences of drug use and addiction (NIDA) and to apply that knowledge to improve individual and public health (NIDA, 2021). National Institute The mission of the National Institute of Environmental Health Sciences of Environmental (NIEHS) is to discover how the environment affects people in order to Health Sciences promote healthier lives (NIEHS, 2019). (NIEHS) PREPUBLICATION COPY—Uncorrected Proofs

488 ENHANCING NIH RESEARCH ON AUTOIMMUNE DISEASE IC Name IC Mission National Insti- The National Institute of General Medical Sciences (NIGMS) supports tute of General basic research that increases our understanding of biological processes Medical Sciences and lays the foundation for advances in disease diagnosis, treatment, (NIGMS) and prevention. NIGMS-funded scientists investigate how living sys- tems work at a range of levels from molecules and cells to tissues and organs, in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enter- prise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacity throughout the country (NIGMS, 2021). National Institute The mission of the National Institute of Mental Health (NIMH) is to of Mental Health transform the understanding and treatment of mental illnesses through (NIMH) basic and clinical research, paving the way for prevention, recovery, and cure (NIMH, 2021). National Institute The mission of the National Institute on Minority Health and Health on Minor- Disparities (NIMHD) is to lead scientific research to improve minor- ity Health and ity health and reduce health disparities. To accomplish this, NIMHD Health Disparities plans, coordinates, reviews, and evaluates NIH minority health and (NIMHD) health disparities research and activities; conducts and supports research in minority health and health disparities; promotes and sup- ports the training of a diverse research workforce; translates and dis- seminates research information; and fosters innovative collaborations and partnerships (NIMHD, 2021). National Institute The mission of the National Institute of Neurological Disorders and of Neurological Stroke (NINDS) is to seek fundamental knowledge about the brain Disorders and and nervous system and to use that knowledge to reduce the burden Stroke (NINDS) of neurological disease for all people. To support this mission, NINDS supports and performs basic, translational, and clinical neuroscience research through grants-in-aid, contracts, scientific meetings, and through research in its own laboratories, and clinics; funds and con- ducts research training and career development programs to increase basic, translational and clinical neuroscience expertise and ensure a vibrant, talented, and diverse work force; promotes the timely dissemi- nation of scientific discoveries and their implications for neurological health to the public, health professionals, researchers, and policy- makers (NINDS, 2021). National Institute The mission of the National Institute of Nursing Research (NINR) is to of Nursing Re- promote and improve the health of individuals, families, and commu- search (NINR) nities. To achieve this mission, NINR supports and conducts clinical and basic research and research training on health and illness, research that spans and integrates the behavioral and biological sciences, and that develops the scientific basis for clinical practice (NIH, 2020). PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX E 489 IC Name IC Mission National Library The National Library of Medicine (NLM) collects, organizes, and of Medicine makes available biomedical science information to scientists, health (NLM) professionals, and the public. The Library’s Web-based databases, including PubMed/Medline and MedlinePlus, are used extensively around the world. NLM conducts and supports research in biomedical communications; creates information resources for molecular biology, biotechnology, toxicology, and environmental health; and provides grant and contract support for training, medical library resources, and biomedical informatics and communications research (NIH, 2019). NIH Clinical The NIH Clinical Center (CC) provides hope through pioneering clini- Center (CC) cal research to improve human health (NIH Clinical Center, 2020). Center for Infor- The Center for Information Technology (CIT) provides the NIH com- mation Technol- munity with a secure and reliable IT infrastructure and a variety of IT ogy (CIT) and scientific computing services that support its mission-critical re- search and administrative activities. Among its activities, CIT provides a robust and secure enterprise network service for NIH staff; state-of- the-art, high-performance scientific computing platforms and applica- tions; secure access to IT systems, including computers and applica- tions; data-processing, hosting, and storage facilities; cloud computing infrastructure, tools, technologies, and other related services; advanced algorithms and data visualization applications; access to discounted software products and applications information, expertise, and training (NIH, 2021). Center for Scien- Since 1946, the Center for Scientific Review (CSR) has worked to see tific Review (CSR) that NIH grant applications receive fair, independent, expert, and timely scientific reviews—free from inappropriate influences—so NIH can fund the most promising research (CSR, 2021). Fogarty Interna- The Fogarty International Center (FIC) is dedicated to advancing the tional Center (FIC) mission of the National Institutes of Health (NIH) by supporting and facilitating global health research conducted by U.S. and international investigators, building partnerships between health research insti- tutions in the U.S. and abroad, and training the next generation of scientists to address global health needs (Fogarty International Center, 2021). National Center The mission of the National Center for Advancing Translational Sci- for Advancing ences (NCATS) is to catalyze the generation of innovative methods Translational Sci- and technologies that will enhance the development, testing and ences (NCATS) implementation of diagnostics and therapeutics across a wide range of human diseases and conditions (NCATS, 2021). National Center The mission of the National Center for Complementary and Integrative for Complementa- Health (NCCIH) is to determine, through rigorous scientific investiga- ry and Integrative tion, the fundamental science, usefulness, and safety of complementary Health (NCCIH) and integrative health approaches and their roles in improving health and health care (NCCIH, 2021). PREPUBLICATION COPY—Uncorrected Proofs

490 ENHANCING NIH RESEARCH ON AUTOIMMUNE DISEASE REFERENCES CSR (Center for Scientific Review). 2021. CSR mission. https://public.csr.nih.gov/AboutC- SR/Mission (accessed December 1, 2021). Fogarty International Center. 2021. Our mission and vision. https://www.fic.nih.gov/About/ Pages/mission-vision.aspx (accessed December 1, 2021). NCATS (National Center for Advancing Translational Sciences). 2021. About the center. https:// ncats.nih.gov/about/center (accessed December 1, 2021). NCCIH (National Center for Complementary and Integrative Health). 2021. About NCCIH. https://www.nccih.nih.gov/about (accessed December 1, 2021). NCI (National Cancer Institute). 2018. National Cancer Institute overview and mission. https:// www.cancer.gov/about-nci/overview (accessed August 6, 2021). NEI (National Eye Institute). 2021. Goals and accomplishments. https://www.nei.nih.gov/ about/goals-and-accomplishments (accessed December 1, 2021). NHGRI (National Human Genome Research Institute). 2018. NHGRI vision and mission. https://www.genome.gov/about-nhgri/NHGRI-Vision-and-Mission (accessed Au- gust 6, 2021). NHLBI (National Heart, Lung, and Blood Institute). 2014. The NHLBI mission statement. https://www.nhlbi.nih.gov/about/mission-statement (accessed November 8, 2021). NIA (National Institute on Aging). 2021. Mission. https://www.nia.nih.gov/about/mission (accessed December 1, 2021). NIAAA (National Institute on Alcohol Abuse and Alcoholism). 2021. Mission statement. https://www.niaaa.nih.gov/our-work/mission-statement (accessed December 1, 2021). NIAID (National Institute of Allergy and Infectious Diseases). 2021. NIAID mission. https:// www.niaid.nih.gov/about/mission-planning-overview (accessed December 1, 2021). NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases). 2021. About NIAMS. https://www.niams.nih.gov/about (accessed December 1, 2021). NIBIB (National Institute of Biomedical Imaging and Bioengineering). 2021. Mission & his- tory. https://www.nibib.nih.gov/about-nibib/mission (accessed December 1, 2021). NICHD (Eunice Kennedy Shriver  National Institute of Child Health and Human Develop- ment). 2019. About NICHD. https://www.nichd.nih.gov/about (accessed August 6, 2021). NIDA (National Institute on Drug Abuse). 2021. About NIDA. https://www.drugabuse.gov/ about-nida (accessed December 1, 2021). NIDCD (National Institute on Deafness and Other Communication Disorders). 2019. Mis- sion. https://www.nidcd.nih.gov/about/mission (accessed December 1, 2021). NIDCR (National Institute of Dental and Craniofacial Research). 2018. Mission. https:// www.nidcr.nih.gov/about-us/mission (accessed December 1, 2021). NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases). 2021. Mission & vision. https://www.niddk.nih.gov/about-niddk/meet-director/mission-vision (ac- cessed December 1, 2021). NIEHS (National Institute of Environmental Health Sciences). 2019. I&IT mission and vi- sion. https://www.niehs.nih.gov/about/strategicplan/informatics-it/mission-vision/ index.cfm (accessed December 1, 2021). NIGMS (National Institute of General Medical Sciences). 2021. About nigms. https://www. nigms.nih.gov/about/Pages/default.aspx#who (accessed December 1, 2021). NIH (National Institutes of Health). 2019. List of NIH institutes, centers, and offices. https:// www.nih.gov/institutes-nih/list-nih-institutes-centers-offices (accessed December 1, 2021). PREPUBLICATION COPY—Uncorrected Proofs

APPENDIX E 491 NIH. 2020. National Institute of Nursing Research (NINR). https://www.nih.gov/about-nih/ what-we-do/nih-almanac/national-institute-nursing-research-ninr (accessed Decem- ber 1, 2021). NIH. 2021. Center for information technology (CIT). https://www.nih.gov/about-nih/what- we-do/nih-almanac/center-information-technology-cit (accessed December 1, 2021). NIH Clinical Center. 2020. Mission and guiding principles. https://clinicalcenter.nih.gov/ about/welcome/mission.html (accessed December 1, 2021). NIMH (National Institute of Mental Health). 2021. About NIMH. https://www.nimh.nih. gov/about (accessed December 1, 2021). NIMHD (National Institute on Minority Health and Health Disparities). 2021. Mission and vision. https://www.nimhd.nih.gov/about/overview/mission-vision.html (accessed December 1, 2021). NINDS (National Institute of Neurological Disorders and Stroke). 2021. NINDS mission. https://www.ninds.nih.gov/About-NINDS/Who-We-Are/Mission (accessed Decem- ber 1, 2021). PREPUBLICATION COPY—Uncorrected Proofs

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Autoimmune diseases occur when the body's immune system malfunctions and mistakenly attacks healthy cells, tissues, and organs. Strong data on the incidence and prevalence of autoimmune diseases are limited, but a 2009 study estimated the prevalence of autoimmune diseases in the U.S. to be 7.6 to 9.4 percent, or 25 to 31 million people today. This estimate, however, includes only 29 autoimmune diseases, and it does not account for increases in prevalence in the last decade. By some counts, there are around 150 autoimmune diseases, which are lifelong chronic illnesses with no known cures. The National Academies of Sciences, Engineering, and Medicine was asked to assess the autoimmune disease research portfolio of the National Institutes of Health (NIH).

Enhancing NIH Research on Autoimmune Disease finds that while NIH has made impressive contributions to research on autoimmune diseases, there is an absence of a strategic NIH-wide autoimmune disease research plan and a need for greater coordination across the institutes and centers to optimize opportunities for collaboration. To meet these challenges, this report calls for the creation of an Office of Autoimmune Disease/Autoimmunity Research in the Office of the Director of NIH. The Office could facilitate NIH-wide collaboration, and engage in prioritizing, budgeting, and evaluating research. Enhancing NIH Research on Autoimmune Disease also calls for the establishment of long term systems to collect epidemiologic and surveillance data and long term studies (20+ years) to study disease across the life course. Finally, the report provides an agenda that highlights research needs that crosscut many autoimmune diseases, such as understanding the effect of environmental factors in initiating disease.

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